NOX4 Mediates Pseudomonas aeruginosa-Induced Nuclear Reactive Oxygen Species Generation and Chromatin Remodeling in Lung Epithelium

Pseudomonas aeruginosa (PA) infection increases reactive oxygen species (ROS), and earlier, we have shown a role for NADPH oxidase-derived ROS in PA-mediated lung inflammation and injury. Here, we show a role for the lung epithelial cell (LEpC) NOX4 in PA-mediated chromatin remodeling and lung infla...

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Detalhes bibliográficos
Publicado no:Antioxidants (Basel)
Main Authors: Fu, Panfeng, Ramchandran, Ramaswamy, Sudhadevi, Tara, Kumar, Prasanth P. K., Krishnan, Yashaswin, Liu, Yuru, Zhao, Yutong, Parinandi, Narasimham L., Harijith, Anantha, Sadoshima, Junichi, Natarajan, Viswanathan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8002602/
https://ncbi.nlm.nih.gov/pubmed/33802941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox10030477
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