IRE1α Is a Therapeutic Target for Cystic Fibrosis Airway Inflammation

New anti-inflammatory treatments are needed for CF airway disease. Studies have implicated the endoplasmic reticulum stress transducer inositol requiring enzyme 1α (IRE1α) in CF airway inflammation. The activation of IRE1α promotes activation of its cytoplasmic kinase and RNase, resulting in mRNA sp...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Hull-Ryde, Emily A., Minges, John T., Martino, Mary E. B., Kato, Takafumi, Norris-Drouin, Jacqueline L., Ribeiro, Carla M. P.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8002512/
https://ncbi.nlm.nih.gov/pubmed/33802742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22063063
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