Ugi Reaction on α-Phosphorated Ketimines for the Synthesis of Tetrasubstituted α-Aminophosphonates and Their Applications as Antiproliferative Agents

An Ugi three-component reaction using preformed α-phosphorated N-tosyl ketimines with different isocyanides in the presence of a carboxylic acid affords tetrasubstituted α-aminophosphonates. Due to the high steric hindrance, the expected acylated amines undergo a spontaneous elimination of the acyl...

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Bibliografische gegevens
Gepubliceerd in:Molecules
Hoofdauteurs: López-Francés, Adrián, del Corte, Xabier, Martínez de Marigorta, Edorta, Palacios, Francisco, Vicario, Javier
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2021
Onderwerpen:
Communication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8002371/
https://ncbi.nlm.nih.gov/pubmed/33809715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26061654
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