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Charged Residues in the Membrane Anchor of the Pestiviral E(rns) Protein Are Important for Processing and Secretion of E(rns) and Recovery of Infectious Viruses

The pestivirus envelope protein E(rns) is anchored in membranes via a long amphipathic helix. Despite the unusual membrane topology of the E(rns) membrane anchor, it is cleaved from the following glycoprotein E1 by cellular signal peptidase. This was proposed to be enabled by a salt bridge-stabilize...

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Detalhes bibliográficos
Publicado no:Viruses
Main Authors: Oetter, Kay-Marcus, Kühn, Juliane, Meyers, Gregor
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8002126/
https://ncbi.nlm.nih.gov/pubmed/33801849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v13030444
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