Paradoxical androgen receptor regulation by small molecule enantiomers

Small molecules that target the androgen receptor (AR) are the mainstay of therapy for lethal castration-resistant prostate cancer (CRPC), yet existing drugs lose their efficacy during continued treatment. This evolution of resistance is due to heterogenous mechanisms which include AR mutations caus...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Patsch, Katherin, Liu, Chao, Zapotoczny, Grzegorz, Sun, Yuanye, Sura, Harish, Ung, Nolan, Sun, Ren X., Haliday, Bethany, Yu, Chen, Aljehani, Mayada, Lee, Jerry S. H., Kashemirov, Boris A., Agus, David B., McKenna, Charles E., Ruderman, Daniel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2021
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000581/
https://ncbi.nlm.nih.gov/pubmed/33741738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2100918118
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