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Paradoxical androgen receptor regulation by small molecule enantiomers

Small molecules that target the androgen receptor (AR) are the mainstay of therapy for lethal castration-resistant prostate cancer (CRPC), yet existing drugs lose their efficacy during continued treatment. This evolution of resistance is due to heterogenous mechanisms which include AR mutations caus...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Proc Natl Acad Sci U S A
Κύριοι συγγραφείς: Patsch, Katherin, Liu, Chao, Zapotoczny, Grzegorz, Sun, Yuanye, Sura, Harish, Ung, Nolan, Sun, Ren X., Haliday, Bethany, Yu, Chen, Aljehani, Mayada, Lee, Jerry S. H., Kashemirov, Boris A., Agus, David B., McKenna, Charles E., Ruderman, Daniel
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2021
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000581/
https://ncbi.nlm.nih.gov/pubmed/33741738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2100918118
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