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Computationally designed pyocyanin demethylase acts synergistically with tobramycin to kill recalcitrant Pseudomonas aeruginosa biofilms

Pseudomonas aeruginosa is an opportunistic human pathogen that develops difficult-to-treat biofilms in immunocompromised individuals, cystic fibrosis patients, and in chronic wounds. P. aeruginosa has an arsenal of physiological attributes that enable it to evade standard antibiotic treatments, part...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: VanDrisse, Chelsey M., Lipsh-Sokolik, Rosalie, Khersonsky, Olga, Fleishman, Sarel J., Newman, Dianne K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000102/
https://ncbi.nlm.nih.gov/pubmed/33723058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022012118
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