Activin A and Cell-Surface GRP78 Are Novel Targetable RhoA Activators for Diabetic Kidney Disease

Diabetic kidney disease (DKD) is the leading cause of kidney failure. RhoA/Rho-associated protein kinase (ROCK) signaling is a recognized mediator of its pathogenesis, largely through mediating the profibrotic response. While RhoA activation is not feasible due to the central role it plays in normal...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Soomro, Asfia, Trink, Jackie, O’Neil, Kian, Li, Renzhong, Naiel, Safaa, Gao, Bo, Ask, Kjetil, Krepinsky, Joan C.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000060/
https://ncbi.nlm.nih.gov/pubmed/33799579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22062839
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