Solubility, Permeability, Anti-Inflammatory Action and In Vivo Pharmacokinetic Properties of Several Mechanochemically Obtained Pharmaceutical Solid Dispersions of Nimesulide

Nimesulide (NIM, N-(4-nitro-2-phenoxyphenyl)methanesulfonamide) is a relatively new nonsteroidal anti-inflammatory analgesic drug. It is practically insoluble in water (<0.02 mg/mL). This very poor aqueous solubility of the drug may lead to low bioavailability. The objective of the present study...

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Bibliografske podrobnosti
izdano v:Molecules
Main Authors: Wei, Wei, Evseenko, Veronica I., Khvostov, Mikhail V., Borisov, Sergey A., Tolstikova, Tatyana G., Polyakov, Nikolay E., Dushkin, Aleksandr V., Xu, Wenhao, Min, Lu, Su, Weike
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7998760/
https://ncbi.nlm.nih.gov/pubmed/33802031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26061513
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