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Mechanisms contributing to ado-trastuzumab emtansine-induced toxicities: a gateway to better understanding of ADC-associated toxicities

In order to improve the safety of novel therapeutic drugs, better understanding of the mechanisms of action is important. Ado-trastuzumab emtansine (also known as T-DM1) is an antibody-drug conjugate (ADC) approved for the treatment of HER2-positive breast cancer. While the treatment with T-DM1 resu...

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Опубликовано в: :Antib Ther
Главные авторы: Endo, Yukinori, Mohan, Nishant, Dokmanovic, Milos, Wu, Wen Jin
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2021
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7998064/
https://ncbi.nlm.nih.gov/pubmed/33937626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/abt/tbab005
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