Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment

BACKGROUND: Central nervous system (CNS) metastases represent a major problem in the treatment of human epidermal growth factor receptor 2 (HER2)–positive breast cancer because of the disappointing efficacy of HER2-targeted therapies against brain lesions. The antibody-drug conjugate ado-trastuzumab...

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Detalhes bibliográficos
Publicado no:J Natl Cancer Inst
Main Authors: Askoxylakis, Vasileios, Ferraro, Gino B., Kodack, David P., Badeaux, Mark, Shankaraiah, Ram C., Seano, Giorgio, Kloepper, Jonas, Vardam, Trupti, Martin, John D., Naxerova, Kamila, Bezwada, Divya, Qi, Xiaolong, Selig, Martin K., Brachtel, Elena, Duda, Dan G., Huang, Peigen, Fukumura, Dai, Engelman, Jeffrey A., Jain, Rakesh K.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862418/
https://ncbi.nlm.nih.gov/pubmed/26547932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv313
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