Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment

BACKGROUND: Central nervous system (CNS) metastases represent a major problem in the treatment of human epidermal growth factor receptor 2 (HER2)–positive breast cancer because of the disappointing efficacy of HER2-targeted therapies against brain lesions. The antibody-drug conjugate ado-trastuzumab...

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書誌詳細
出版年:J Natl Cancer Inst
主要な著者: Askoxylakis, Vasileios, Ferraro, Gino B., Kodack, David P., Badeaux, Mark, Shankaraiah, Ram C., Seano, Giorgio, Kloepper, Jonas, Vardam, Trupti, Martin, John D., Naxerova, Kamila, Bezwada, Divya, Qi, Xiaolong, Selig, Martin K., Brachtel, Elena, Duda, Dan G., Huang, Peigen, Fukumura, Dai, Engelman, Jeffrey A., Jain, Rakesh K.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2015
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862418/
https://ncbi.nlm.nih.gov/pubmed/26547932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv313
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