Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment

BACKGROUND: Central nervous system (CNS) metastases represent a major problem in the treatment of human epidermal growth factor receptor 2 (HER2)–positive breast cancer because of the disappointing efficacy of HER2-targeted therapies against brain lesions. The antibody-drug conjugate ado-trastuzumab...

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Publicat a:J Natl Cancer Inst
Autors principals: Askoxylakis, Vasileios, Ferraro, Gino B., Kodack, David P., Badeaux, Mark, Shankaraiah, Ram C., Seano, Giorgio, Kloepper, Jonas, Vardam, Trupti, Martin, John D., Naxerova, Kamila, Bezwada, Divya, Qi, Xiaolong, Selig, Martin K., Brachtel, Elena, Duda, Dan G., Huang, Peigen, Fukumura, Dai, Engelman, Jeffrey A., Jain, Rakesh K.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862418/
https://ncbi.nlm.nih.gov/pubmed/26547932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv313
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