miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease

Aberrant regulation of microRNAs (miRNAs) has been implicated in the pathogenesis of Alzheimer’s disease (AD), but most abnormally expressed miRNAs found in AD are not regulated by synaptic activity. Here we report that dysfunction of miR-135a-5p/Rock2/Add1 results in memory/synaptic disorder in a m...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zheng, Kai, Hu, Fan, Zhou, Yang, Zhang, Juan, Zheng, Jie, Lai, Chuan, Xiong, Wan, Cui, Ke, Hu, Ya-Zhuo, Han, Zhi-Tao, Zhang, Hong-Hong, Chen, Jian-Guo, Man, Heng-Ye, Liu, Dan, Lu, Youming, Zhu, Ling-Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7998005/
https://ncbi.nlm.nih.gov/pubmed/33771994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22196-y
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