Inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice

Atherosclerosis and obesity share pathological features including inflammation mediated by innate and adaptive immune cells. LXRα plays a central role in the transcription of inflammatory and metabolic genes. LXRα is modulated by phosphorylation at serine 196 (LXRα pS196), however, the consequences...

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Publicado no:Commun Biol
Main Authors: Voisin, Maud, Shrestha, Elina, Rollet, Claire, Nikain, Cyrus A., Josefs, Tatjana, Mahé, Mélanie, Barrett, Tessa J., Chang, Hye Rim, Ruoff, Rachel, Schneider, Jeffrey A., Garabedian, Michela L., Zoumadakis, Chris, Yun, Chi, Badwan, Bara, Brown, Emily J., Mar, Adam C., Schneider, Robert J., Goldberg, Ira J., Pineda-Torra, Inés, Fisher, Edward A., Garabedian, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7997930/
https://ncbi.nlm.nih.gov/pubmed/33772096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01925-5
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