Identification of SARS-CoV-2 viral entry inhibitors using machine learning and cell-based pseudotyped particle assay

In response to the pandemic caused by SARS-CoV-2, we constructed a hybrid support vector machine (SVM) classification model using a set of publicly posted SARS-CoV-2 pseudotyped particle (PP) entry assay repurposing screen data to identify novel potent compounds as a starting point for drug developm...

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Pubblicato in:Bioorg Med Chem
Autori principali: Sun, Hongmao, Wang, Yuhong, Chen, Catherine Z., Xu, Miao, Guo, Hui, Itkin, Misha, Zheng, Wei, Shen, Min
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Science 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7997310/
https://ncbi.nlm.nih.gov/pubmed/33831697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2021.116119
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