Short-term treatment of golden retriever muscular dystrophy (GRMD) dogs with rAAVrh74.MHCK7.GALGT2 induces muscle glycosylation and utrophin expression but has no significant effect on muscle strength

We have examined the effects of intravenous (IV) delivery of rAAVrh74.MHCK7.GALGT2 in the golden retriever muscular dystrophy (GRMD) model of Duchenne Muscular Dystrophy (DMD). After baseline testing, GRMD dogs were treated at 3 months of age and reassessed at 6 months. This 3–6 month age range is a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Martin, Paul T., Zygmunt, Deborah A., Ashbrook, Anna, Hamilton, Sonia, Packer, Davin, Birch, Sharla M., Bettis, Amanda K., Balog-Alvarez, Cynthia J., Guo, Lee-Jae, Nghiem, Peter P., Kornegay, Joe N.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7997012/
https://ncbi.nlm.nih.gov/pubmed/33770101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0248721
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