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Coupled Feedback Loops Involving PAGE4, EMT and Notch Signaling Can Give Rise to Non-Genetic Heterogeneity in Prostate Cancer Cells

Non-genetic heterogeneity is emerging as a crucial factor underlying therapy resistance in multiple cancers. However, the design principles of regulatory networks underlying non-genetic heterogeneity in cancer remain poorly understood. Here, we investigate the coupled dynamics of feedback loops invo...

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Foilsithe in:Entropy (Basel)
Main Authors: Singh, Divyoj, Bocci, Federico, Kulkarni, Prakash, Jolly, Mohit Kumar
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2021
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7996788/
https://ncbi.nlm.nih.gov/pubmed/33652914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/e23030288
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