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A Novel One-Pot Enzyme Cascade for the Biosynthesis of Cladribine Triphosphate

Cladribine triphosphate is the active compound of the anti-cancer and multiple sclerosis drug Mavenclad (cladribine). Biosynthesis of such non-natural deoxyribonucleotides is challenging but important in order to study the pharmaceutical modes of action. In this study, we developed a novel one-pot e...

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Publicat a:Biomolecules
Autors principals: Frisch, Julia, Maršić, Tin, Loderer, Christoph
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7996316/
https://ncbi.nlm.nih.gov/pubmed/33668847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11030346
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