One pot synthesis of GDP‐mannose by a multi‐enzyme cascade for enzymatic assembly of lipid‐linked oligosaccharides

Glycosylation of proteins is a key function of the biosynthetic‐secretory pathway in the endoplasmic reticulum (ER) and Golgi apparatus. Glycosylated proteins play a crucial role in cell trafficking and signaling, cell‐cell adhesion, blood‐group antigenicity, and immune response. In addition, the gl...

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Bibliographic Details
Published in:Biotechnol Bioeng
Main Authors: Rexer, Thomas F.T., Schildbach, Anna, Klapproth, Jan, Schierhorn, Angelika, Mahour, Reza, Pietzsch, Markus, Rapp, Erdmann, Reichl, Udo
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765510/
https://ncbi.nlm.nih.gov/pubmed/28922469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.26454
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