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Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles

Ionizable lipid nanoparticles (LNPs) are the most clinically advanced nano‐delivery system for therapeutic nucleic acids. The great effort put in the development of ionizable lipids with increased in vivo potency brought LNPs from the laboratory benches to the FDA approval of patisiran in 2018 and t...

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Detalles Bibliográficos
Publicado en:Bioeng Transl Med
Main Authors: Schlich, Michele, Palomba, Roberto, Costabile, Gabriella, Mizrahy, Shoshy, Pannuzzo, Martina, Peer, Dan, Decuzzi, Paolo
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley & Sons, Inc. 2021
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7995196/
https://ncbi.nlm.nih.gov/pubmed/33786376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/btm2.10213
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