Sulfoglycodendrimer Therapeutics for HIV‐1 and SARS‐CoV‐2

Hexavalent sulfoglycodendrimers (SGDs) are synthesized as mimics of host cell heparan sulfate proteoglycans (HSPGs) to inhibit the early stages in viral binding/entry of HIV‐1 and SARS‐CoV‐2. Using an HIV neutralization assay, the most promising of the seven candidates are found to have sub‐micromol...

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Bibliografiske detaljer
Udgivet i:Adv Ther (Weinh)
Main Authors: Wells, Lauren, Vierra, Cory, Hardman, Janee’, Han, Yanxiao, Dimas, Dustin, Gwarada‐Phillips, Lucia N., Blackeye, Rachel, Eggers, Daryl K., LaBranche, Celia C., Král, Petr, McReynolds, Katherine D.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2021
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Full Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7995185/
https://ncbi.nlm.nih.gov/pubmed/33786368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adtp.202000210
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