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Treatment With Calcineurin Inhibitor FK506 Attenuates Noise-Induced Hearing Loss

Attenuation of noise-induced hair cell loss and noise-induced hearing loss (NIHL) by treatment with FK506 (tacrolimus), a calcineurin (CaN/PP2B) inhibitor used clinically as an immunosuppressant, has been previously reported, but the downstream mechanisms of FK506-attenuated NIHL remain unknown. Her...

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Bibliographische Detailangaben
Veröffentlicht in:Front Cell Dev Biol
Hauptverfasser: He, Zu-Hong, Pan, Song, Zheng, Hong-Wei, Fang, Qiao-Jun, Hill, Kayla, Sha, Su-Hua
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994600/
https://ncbi.nlm.nih.gov/pubmed/33777956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.648461
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