New insights into structure and function of bis-phosphinic acid derivatives and implications for CFTR modulation

C407 is a compound that corrects the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein carrying the p.Phe508del (F508del) mutation. We investigated the corrector effect of c407 and its derivatives on F508del-CFTR protein. Molecular docking and dynamics simulations combined with site...

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Publicado no:Sci Rep
Main Authors: Bitam, Sara, Elbahnsi, Ahmad, Creste, Geordie, Pranke, Iwona, Chevalier, Benoit, Berhal, Farouk, Hoffmann, Brice, Servel, Nathalie, Baatalah, Nesrine, Tondelier, Danielle, Hatton, Aurelie, Moquereau, Christelle, Faria Da Cunha, Mélanie, Pastor, Alexandra, Lepissier, Agathe, Hinzpeter, Alexandre, Mornon, Jean-Paul, Prestat, Guillaume, Edelman, Aleksander, Callebaut, Isabelle, Gravier-Pelletier, Christine, Sermet-Gaudelus, Isabelle
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994384/
https://ncbi.nlm.nih.gov/pubmed/33767236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83240-x
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