Tumor DNA methylation profiles correlate with response to anti-PD-1 immune checkpoint inhibitor monotherapy in sarcoma patients

BACKGROUND: Some sarcomas respond to immune checkpoint inhibition, but predictive biomarkers are unknown. We analyzed tumor DNA methylation profiles in relation to immunological parameters and response to anti-programmed cell death 1 (anti-PD-1) immune checkpoint inhibitor (ICI) therapy in patients...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Starzer, Angelika M, Berghoff, Anna S, Hamacher, Rainer, Tomasich, Erwin, Feldmann, Katharina, Hatziioannou, Teresa, Traint, Stefan, Lamm, Wolfgang, Noebauer-Huhmann, Iris M, Furtner, Julia, Müllauer, Leonhard, Amann, Gabriele, Bauer, Sebastian, Schildhaus, Hans-Ulrich, Preusser, Matthias, Heller, Gerwin, Brodowicz, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Immunotherapy Biomarkers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7993298/
https://ncbi.nlm.nih.gov/pubmed/33762319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001458
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