Glioblastoma cell populations with distinct oncogenic programs release podoplanin as procoagulant extracellular vesicles

Vascular anomalies, including local and peripheral thrombosis, are a hallmark of glioblastoma (GBM) and an aftermath of deregulation of the cancer cell genome and epigenome. Although the molecular effectors of these changes are poorly understood, the upregulation of podoplanin (PDPN) by cancer cells...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Tawil, Nadim, Bassawon, Rayhaan, Meehan, Brian, Nehme, Ali, Montermini, Laura, Gayden, Tenzin, De Jay, Nicolas, Spinelli, Cristiana, Chennakrishnaiah, Shilpa, Choi, Dongsic, Adnani, Lata, Zeinieh, Michele, Jabado, Nada, Kleinman, Claudia L., Witcher, Michael, Riazalhosseini, Yasser, Key, Nigel S., Schiff, David, Grover, Steven P., Mackman, Nigel, Couturier, Charles P., Petrecca, Kevin, Suvà, Mario L., Patel, Anoop, Tirosh, Itay, Najafabadi, Hamed, Rak, Janusz
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7993100/
https://ncbi.nlm.nih.gov/pubmed/33720339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002998
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