The CD33 short isoform is a gain-of-function variant that enhances Aβ(1–42) phagocytosis in microglia

BACKGROUND: CD33 is genetically linked to Alzheimer’s disease (AD) susceptibility through differential expression of isoforms in microglia. The role of the human CD33 short isoform (hCD33m), preferentially encoded by an AD-protective CD33 allele (rs12459419T), is unknown. Here, we test whether hCD33...

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Vydáno v:Mol Neurodegener
Hlavní autoři: Bhattacherjee, Abhishek, Jung, Jaesoo, Zia, Sameera, Ho, Madelene, Eskandari-Sedighi, Ghazaleh, St. Laurent, Chris D., McCord, Kelli A., Bains, Arjun, Sidhu, Gaurav, Sarkar, Susmita, Plemel, Jason R., Macauley, Matthew S.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7992807/
https://ncbi.nlm.nih.gov/pubmed/33766097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-021-00443-6
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