Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis

The oncogene DEK is found fused with the NUP214 gene creating oncoprotein DEK-NUP214 that induces acute myeloid leukemia (AML) in patients, and secreted DEK protein functions as a hematopoietic cytokine to regulate hematopoiesis; however, the intrinsic role of nuclear DEK in hematopoietic stem cells...

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Publicado no:J Exp Med
Main Authors: Chen, Zhe, Huo, Dawei, Li, Lei, Liu, Zhilong, Li, Zhigang, Xu, Shuangnian, Huang, Yongxiu, Wu, Weiru, Zhou, Chengfang, Liu, Yuanyuan, Kuang, Mei, Wu, Feng, Li, Hui, Qian, Pengxu, Song, Guanbin, Wu, Xudong, Chen, Jieping, Hou, Yu
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7992411/
https://ncbi.nlm.nih.gov/pubmed/33755722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201974
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