The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors

G-protein-coupled receptors (GPCRs) are the most important signal transducers in higher eukaryotes. Despite considerable progress, the molecular basis of subtype-specific ligand selectivity, especially for peptide receptors, remains unknown. Here, by integrating DNP-enhanced solid-state NMR spectros...

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Gepubliceerd in:Nat Chem Biol
Hoofdauteurs: Joedicke, Lisa, Mao, Jiafei, Kuenze, Georg, Reinhart, Christoph, Kalavacherla, Tejaswi, Jonker, Hendrik R A, Richter, Christian, Schwalbe, Harald, Meiler, Jens, Preu, Julia, Michel, Hartmut, Glaubitz, Clemens
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7992120/
https://ncbi.nlm.nih.gov/pubmed/29334381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2551
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