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The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats

In this protocol, we detail the correct procedural steps and necessary precautions to successfully perform a left pneumonectomy and induce PAH in rats with the additional administration of monocrotaline (MCT) or SU5416 (Sugen). We also compare these two models to other PAH models commonly used in re...

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Detalhes bibliográficos
Publicado no:J Vis Exp
Main Authors: Katz, Michael G., Fargnoli, Anthony S., Gubara, Sarah M., Bisserier, Malik, Sassi, Yassine, Bridges, Charles R., Hajjar, Roger J., Hadri, Lahouaria
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7992111/
https://ncbi.nlm.nih.gov/pubmed/30907889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/59050
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