Sox2-Evf2 lncRNA-mediated mechanisms of chromosome topological control in developing forebrain

The Evf2 long non-coding RNA directs Dlx5/6 ultraconserved enhancer(UCE)-intrachromosomal interactions, regulating genes across a 27 Mb region on chromosome 6 in mouse developing forebrain. Here, we show that Evf2 long-range gene repression occurs through multi-step mechanisms involving the transcri...

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Bibliografiske detaljer
Udgivet i:Development
Main Authors: Cajigas, Ivelisse, Chakraborty, Abhijit, Lynam, Madison, Swyter, Kelsey R., Bastidas, Monique, Collens, Linden, Luo, Hao, Ay, Ferhat, Kohtz, Jhumku D.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7990859/
https://ncbi.nlm.nih.gov/pubmed/33593819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.197202
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