The Evf2 ultraconserved enhancer lncRNA functionally and spatially organizes multi-megabase distant genes in developing forebrain

Gene regulation requires selective targeting of DNA regulatory enhancers over megabase (Mb) distances. Here, we show that Evf2, a cloud-forming Dlx5/6 ultraconserved enhancer (UCE) lncRNA simultaneously localizes to activated (Umad1, 1.6Mb distant) and repressed (Akr1b8, 27Mb distant) chr6 target ge...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Cajigas, Ivelisse, Chakraborty, Abhijit, Swyter, Kelsey R., Luo, Hao, Bastidas, Monique, Nigro, Maximilliano, Morris, Elizabeth R., Chen, Sean, VanGompel, Michael J. W., Leib, David, Kohtz, Sara J., Martina, Marco, Koh, Sooky, Ay, Ferhat, Kohtz, Jhumku D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428050/
https://ncbi.nlm.nih.gov/pubmed/30146317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.07.024
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