The Evf2 ultraconserved enhancer lncRNA functionally and spatially organizes multi-megabase distant genes in developing forebrain

Gene regulation requires selective targeting of DNA regulatory enhancers over megabase (Mb) distances. Here, we show that Evf2, a cloud-forming Dlx5/6 ultraconserved enhancer (UCE) lncRNA simultaneously localizes to activated (Umad1, 1.6Mb distant) and repressed (Akr1b8, 27Mb distant) chr6 target ge...

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書誌詳細
出版年:Mol Cell
主要な著者: Cajigas, Ivelisse, Chakraborty, Abhijit, Swyter, Kelsey R., Luo, Hao, Bastidas, Monique, Nigro, Maximilliano, Morris, Elizabeth R., Chen, Sean, VanGompel, Michael J. W., Leib, David, Kohtz, Sara J., Martina, Marco, Koh, Sooky, Ay, Ferhat, Kohtz, Jhumku D.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428050/
https://ncbi.nlm.nih.gov/pubmed/30146317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.07.024
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