Ca(2+) signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG

Calcium signaling regulated by the cGMP-dependent protein kinase (PKG) controls key life cycle transitions in the malaria parasite. However, how calcium is mobilized from intracellular stores in the absence of canonical calcium channels in Plasmodium is unknown. Here, we identify a multipass membran...

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發表在:Sci Adv
Main Authors: Balestra, Aurélia C., Koussis, Konstantinos, Klages, Natacha, Howell, Steven A., Flynn, Helen R., Bantscheff, Marcus, Pasquarello, Carla, Perrin, Abigail J., Brusini, Lorenzo, Arboit, Patrizia, Sanz, Olalla, Castaño, Laura Peces-Barba, Withers-Martinez, Chrislaine, Hainard, Alexandre, Ghidelli-Disse, Sonja, Snijders, Ambrosius P., Baker, David A., Blackman, Michael J., Brochet, Mathieu
格式: Artigo
語言:Inglês
出版: American Association for the Advancement of Science 2021
主題:
Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7990342/
https://ncbi.nlm.nih.gov/pubmed/33762339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe5396
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