Secretory mucin 5AC promotes neoplastic progression by augmenting KLF4-mediated pancreatic cancer cell stemness

Secreted mucin 5AC (MUC5AC) is the most abundantly overexpressed member of the mucin family during early pancreatic intraepithelial neoplasia stage I (PanIN-I) of pancreatic cancer (PC). To comprehend the contribution of Muc5ac in PC pathology, we genetically ablated it in an autochthonous murine mo...

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Pubblicato in:Cancer Res
Autori principali: Ganguly, Koelina, Krishn, Shiv Ram, Rachagani, Satyanarayana, Jahan, Rahat, Shah, Ashu, Nallasamy, Palanisamy, Rauth, Sanchita, Atri, Pranita, Cox, Jesse L., Pothuraju, Ramesh, Smith, Lynette M., Ayala, Sudhua, Evans, Christopher, Ponnusamy, Moorthy P., Kumar, Sushil, Kaur, Sukhwinder, Batra, Surinder K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7990052/
https://ncbi.nlm.nih.gov/pubmed/33127746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-1293
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