Secretory mucin 5AC promotes neoplastic progression by augmenting KLF4-mediated pancreatic cancer cell stemness

Secreted mucin 5AC (MUC5AC) is the most abundantly overexpressed member of the mucin family during early pancreatic intraepithelial neoplasia stage I (PanIN-I) of pancreatic cancer (PC). To comprehend the contribution of Muc5ac in PC pathology, we genetically ablated it in an autochthonous murine mo...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Ganguly, Koelina, Krishn, Shiv Ram, Rachagani, Satyanarayana, Jahan, Rahat, Shah, Ashu, Nallasamy, Palanisamy, Rauth, Sanchita, Atri, Pranita, Cox, Jesse L., Pothuraju, Ramesh, Smith, Lynette M., Ayala, Sudhua, Evans, Christopher, Ponnusamy, Moorthy P., Kumar, Sushil, Kaur, Sukhwinder, Batra, Surinder K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7990052/
https://ncbi.nlm.nih.gov/pubmed/33127746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-1293
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