Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling

BACKGROUND: Mitochondrial dysfunction is a common feature of aging, neurodegeneration, and metabolic diseases. Hence, mitotherapeutics may be valuable disease modifiers for a large number of conditions. In this study, we have set up a large-scale screening platform for mitochondrial-based modulators...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:BMC Biol
المؤلفون الرئيسيون: Naia, Luana, Pinho, Catarina M., Dentoni, Giacomo, Liu, Jianping, Leal, Nuno Santos, Ferreira, Duarte M. S., Schreiner, Bernadette, Filadi, Riccardo, Fão, Lígia, Connolly, Niamh M. C., Forsell, Pontus, Nordvall, Gunnar, Shimozawa, Makoto, Greotti, Elisa, Basso, Emy, Theurey, Pierre, Gioran, Anna, Joselin, Alvin, Arsenian-Henriksson, Marie, Nilsson, Per, Rego, A. Cristina, Ruas, Jorge L., Park, David, Bano, Daniele, Pizzo, Paola, Prehn, Jochen H. M., Ankarcrona, Maria
التنسيق: Artigo
اللغة:Inglês
منشور في: BioMed Central 2021
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC7989211/
https://ncbi.nlm.nih.gov/pubmed/33761951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-021-00979-5
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