Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons

Mitochondrial dysfunction is implicated in most neurodegenerative diseases, including Alzheimer's disease (AD). We here combined experimental and computational approaches to investigate mitochondrial health and bioenergetic function in neurons from a double transgenic animal model of AD (PS2APP...

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Foilsithe in:Aging Cell
Main Authors: Theurey, Pierre, Connolly, Niamh M. C., Fortunati, Ilaria, Basso, Emy, Lauwen, Susette, Ferrante, Camilla, Moreira Pinho, Catarina, Joselin, Alvin, Gioran, Anna, Bano, Daniele, Park, David S., Ankarcrona, Maria, Pizzo, Paola, Prehn, Jochen H. M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2019
Ábhair:
Original Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516149/
https://ncbi.nlm.nih.gov/pubmed/30793475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12924
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