Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons

Mitochondrial dysfunction is implicated in most neurodegenerative diseases, including Alzheimer's disease (AD). We here combined experimental and computational approaches to investigate mitochondrial health and bioenergetic function in neurons from a double transgenic animal model of AD (PS2APP...

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發表在:Aging Cell
Main Authors: Theurey, Pierre, Connolly, Niamh M. C., Fortunati, Ilaria, Basso, Emy, Lauwen, Susette, Ferrante, Camilla, Moreira Pinho, Catarina, Joselin, Alvin, Gioran, Anna, Bano, Daniele, Park, David S., Ankarcrona, Maria, Pizzo, Paola, Prehn, Jochen H. M.
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2019
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516149/
https://ncbi.nlm.nih.gov/pubmed/30793475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12924
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