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Pannexin 1 channels control the hemodynamic response to hypoxia by regulating O(2)-sensitive extracellular ATP in blood

Pannexin 1 (Panx1) channels export ATP and may contribute to increased concentration of the vasodilator ATP in plasma during hypoxia in vivo. We hypothesized that Panx1 channels and associated ATP export contribute to hypoxic vasodilation, a mechanism that facilitates the matching of oxygen delivery...

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Publicat a:Am J Physiol Heart Circ Physiol
Autors principals: Kirby, Brett S., Sparks, Matthew A., Lazarowski, Eduardo R., Lopez Domowicz, Denise A., Zhu, Hongmei, McMahon, Timothy J.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988759/
https://ncbi.nlm.nih.gov/pubmed/33449849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00651.2020
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