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Pannexin 1 channels control the hemodynamic response to hypoxia by regulating O(2)-sensitive extracellular ATP in blood

Pannexin 1 (Panx1) channels export ATP and may contribute to increased concentration of the vasodilator ATP in plasma during hypoxia in vivo. We hypothesized that Panx1 channels and associated ATP export contribute to hypoxic vasodilation, a mechanism that facilitates the matching of oxygen delivery...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Kirby, Brett S., Sparks, Matthew A., Lazarowski, Eduardo R., Lopez Domowicz, Denise A., Zhu, Hongmei, McMahon, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988759/
https://ncbi.nlm.nih.gov/pubmed/33449849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00651.2020
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