Application of a small molecule inhibitor screen approach to identify CXCR4 downstream signaling pathways that promote a mesenchymal and fulvestrant-resistant phenotype in breast cancer cells

Chemokine receptor 4 (CXCR4) and its ligand stromal-derived factor 1 (SDF-1) have well-characterized functions in cancer metastasis; however, the specific mechanisms through which CXCR4 promotes a metastatic and drug-resistant phenotype remain widely unknown. The aim of the present study was to demo...

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Publicado no:Oncol Lett
Main Authors: Matossian, Margarite D., Elliott, Steven, Rhodes, Lyndsay V., Martin, Elizabeth C., Hoang, Van T., Burks, Hope E., Zuercher, William J., Drewry, David H., Collins-Burow, Bridgette M., Burow, Matthew E.
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2021
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988660/
https://ncbi.nlm.nih.gov/pubmed/33777204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2021.12641
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