Engineering of highly potent and selective HNTX-III mutant against hNa(v)1.7 sodium channel for treatment of pain

Human voltage-gated sodium channel Na(v)1.7 (hNa(v)1.7) is involved in the generation and conduction of neuropathic and nociceptive pain signals. Compelling genetic and preclinical studies have validated that hNa(v)1.7 is a therapeutic target for the treatment of pain; however, there is a dearth of...

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Udgivet i:J Biol Chem
Main Authors: Zhang, Yunxiao, Wang, Li, Peng, Dezheng, Zhang, Qingfeng, Yang, Qiuchu, Li, Jiayan, Li, Dan, Tang, Dongfang, Chen, Minzhi, Liang, Songping, Liu, Yu, Wang, Sheng, Liu, Zhonghua
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988488/
https://ncbi.nlm.nih.gov/pubmed/33493520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100326
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