Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis

The major lysosomal proteases, Cathepsin B (CTSB), Cathepsin D (CTSD) and Cathepsin L (CTSL), are implicated in autophagic activity. To investigate the role of each cathepsin in the exocrine pancreas, we generated mice in which the pancreas was specifically deficient in Ctsb, Ctsd and Ctsl. Each of...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Iwama, Hideaki, Mehanna, Sally, Imasaka, Mai, Hashidume, Shinsuke, Nishiura, Hiroshi, Yamamura, Ken-ichi, Suzuki, Chigure, Uchiyama, Yasuo, Hatano, Etsuro, Ohmuraya, Masaki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988038/
https://ncbi.nlm.nih.gov/pubmed/33758261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85898-9
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