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A chlorzoxazone-baclofen combination improves cerebellar impairment in spinocerebellar ataxia type 1

BACKGROUND: A combination of central muscle relaxants, chlorzoxazone and baclofen (chlorzoxazone-baclofen), has been proposed for treatment of cerebellar symptoms in human spinocerebellar ataxia (SCA). However, central muscle relaxants can worsen balance. The optimal dose for target engagement witho...

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Udgivet i:Mov Disord
Main Authors: Bushart, David D., Huang, Haoran, Man, Luke J., Morrison, Logan M., Shakkottai, Vikram G.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7987844/
https://ncbi.nlm.nih.gov/pubmed/33151010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.28355
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