Soluble TIM3 and Its Ligands Galectin-9 and CEACAM1 Are in Disequilibrium During Alcohol-Related Liver Disease and Promote Impairment of Anti-bacterial Immunity

BACKGROUND AND AIMS: Immunoregulatory checkpoint receptors (CR) contribute to the profound immunoparesis observed in alcohol-related liver disease (ALD) and in vitro neutralization of inhibitory-CRs TIM3/PD1 on anti-bacterial T-cells can rescue innate and adaptive anti-bacterial immunity. Recently d...

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Gepubliceerd in:Front Physiol
Hoofdauteurs: Riva, Antonio, Palma, Elena, Devshi, Dhruti, Corrigall, Douglas, Adams, Huyen, Heaton, Nigel, Menon, Krishna, Preziosi, Melissa, Zamalloa, Ane, Miquel, Rosa, Ryan, Jennifer M., Wright, Gavin, Fairclough, Sarah, Evans, Alexander, Shawcross, Debbie, Schierwagen, Robert, Klein, Sabine, Uschner, Frank E., Praktiknjo, Michael, Katzarov, Krum, Hadzhiolova, Tanya, Pavlova, Slava, Simonova, Marieta, Trebicka, Jonel, Williams, Roger, Chokshi, Shilpa
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2021
Onderwerpen:
Physiology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7987668/
https://ncbi.nlm.nih.gov/pubmed/33776793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.632502
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