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Soluble TIM3 and Its Ligands Galectin-9 and CEACAM1 Are in Disequilibrium During Alcohol-Related Liver Disease and Promote Impairment of Anti-bacterial Immunity

BACKGROUND AND AIMS: Immunoregulatory checkpoint receptors (CR) contribute to the profound immunoparesis observed in alcohol-related liver disease (ALD) and in vitro neutralization of inhibitory-CRs TIM3/PD1 on anti-bacterial T-cells can rescue innate and adaptive anti-bacterial immunity. Recently d...

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發表在:Front Physiol
Main Authors: Riva, Antonio, Palma, Elena, Devshi, Dhruti, Corrigall, Douglas, Adams, Huyen, Heaton, Nigel, Menon, Krishna, Preziosi, Melissa, Zamalloa, Ane, Miquel, Rosa, Ryan, Jennifer M., Wright, Gavin, Fairclough, Sarah, Evans, Alexander, Shawcross, Debbie, Schierwagen, Robert, Klein, Sabine, Uschner, Frank E., Praktiknjo, Michael, Katzarov, Krum, Hadzhiolova, Tanya, Pavlova, Slava, Simonova, Marieta, Trebicka, Jonel, Williams, Roger, Chokshi, Shilpa
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2021
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7987668/
https://ncbi.nlm.nih.gov/pubmed/33776793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.632502
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