Apolipoprotein A-I in mouse cerebrospinal fluid derives from the liver and intestine via plasma high-density lipoproteins assembled by ABCA1 and LCAT

Apolipoprotein (apo) A-I, the major structural protein of high-density lipoprotein (HDL), is present in human and mouse cerebrospinal fluid (CSF) despite its lack of expression in brain cells. To identify the origin of apoA-I in CSF, we generated intestine-specific and liver-specific Apoa1 knockout...

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Veröffentlicht in:FEBS Lett
Hauptverfasser: Tsujita, Maki, Vaisman, Boris, Chengyu, Liu, Vickers, Kasey C., Okuhira, Kei-ichiro, Braesch-Andersen, Sten, Remaley, Alan T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7987658/
https://ncbi.nlm.nih.gov/pubmed/33020907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.13950
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