A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition

Polo-like kinase 4 (PLK4) is canonically known for its cytoplasmic function in centriole duplication. Here we show a noncanonical PLK4 function of regulating the transcription factor SRF’s nuclear activity and associated myofibroblast-like cell-type transition. In this context, we have further found...

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Detalhes bibliográficos
Publicado no:JACC Basic Transl Sci
Main Authors: Li, Jing, Urabe, Go, Huang, Yitao, Zhang, Mengxue, Wang, Bowen, Marcho, Lynn, Shen, Hongtao, Kent, K. Craig, Guo, Lian-Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Preclinical Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7987547/
https://ncbi.nlm.nih.gov/pubmed/33778212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2020.12.015
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