Reactive Oxygen Species Regulate Endoplasmic Reticulum Stress and ER-Mitochondrial Ca(2+) Crosstalk to Promote Programmed Necrosis of Rat Nucleus Pulposus Cells under Compression

Programmed necrosis of nucleus pulposus (NP) cells caused by excessive compression is a crucial factor in the etiopathogenesis of intervertebral disc degeneration (IVDD). The endoplasmic reticulum (ER) and mitochondria are crucial regulators of the cell death signaling pathway, and their involvement...

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Veröffentlicht in:Oxid Med Cell Longev
Hauptverfasser: Lin, Hui, Peng, Yizhong, Li, Jinye, Wang, Zhe, Chen, Sheng, Qing, Xiangcheng, Pu, Feifei, Lei, Ming, Shao, Zengwu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2021
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7987452/
https://ncbi.nlm.nih.gov/pubmed/33815661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/8810698
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