Time-resolved serial femtosecond crystallography reveals early structural changes in channelrhodopsin

Channelrhodopsins (ChRs) are microbial light-gated ion channels utilized in optogenetics to control neural activity with light . Light absorption causes retinal chromophore isomerization and subsequent protein conformational changes visualized as optically distinguished intermediates, coupled with c...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Oda, Kazumasa, Nomura, Takashi, Nakane, Takanori, Yamashita, Keitaro, Inoue, Keiichi, Ito, Shota, Vierock, Johannes, Hirata, Kunio, Maturana, Andrés D, Katayama, Kota, Ikuta, Tatsuya, Ishigami, Itsuki, Izume, Tamaki, Umeda, Rie, Eguma, Ryuun, Oishi, Satomi, Kasuya, Go, Kato, Takafumi, Kusakizako, Tsukasa, Shihoya, Wataru, Shimada, Hiroto, Takatsuji, Tomoyuki, Takemoto, Mizuki, Taniguchi, Reiya, Tomita, Atsuhiro, Nakamura, Ryoki, Fukuda, Masahiro, Miyauchi, Hirotake, Lee, Yongchan, Nango, Eriko, Tanaka, Rie, Tanaka, Tomoyuki, Sugahara, Michihiro, Kimura, Tetsunari, Shimamura, Tatsuro, Fujiwara, Takaaki, Yamanaka, Yasuaki, Owada, Shigeki, Joti, Yasumasa, Tono, Kensuke, Ishitani, Ryuichiro, Hayashi, Shigehiko, Kandori, Hideki, Hegemann, Peter, Iwata, So, Kubo, Minoru, Nishizawa, Tomohiro, Nureki, Osamu
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Structural Biology and Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7987342/
https://ncbi.nlm.nih.gov/pubmed/33752801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.62389
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